Dr. R. K. Bammi, formerly President of Sabinsa Corporation's
R&D in New Jersey, has accepted a new position
as the Director of Sami Chemicals & Extracts,
Sabinsa Corporation's manufacturing facility in
India, where he will oversee operations. We wish
him success in his new position!
Dr. N. Kalyanam has recently
joined Sabinsa's New Jersey R&D as President.
His research interests are synthetic methodology
and chiral chemistry. He obtained his M.Sc. in
Chemistry at the University of Madras and Ph.D.
in Organic Chemistry from Baylor University (Texas).
Upon completing his Ph.D., Dr. Kalyanam completed
2 years of postdoctoral studies focusing on organic
synthesis procedures before returning to India.
In India he worked for a number of reputable companies,
IPCL, Ciba Geigy, and SPIC Pharma, to which he
made major scientific contributions.Dr. Kalyanam's
primary responsibilities at Sabinsa include the
development of efficient and novel scientific
routes for xenobiotics and intermediates as well
as the exploration of new business areas. We welcome
Dr. Kalyanam aboard!
Habibullah: New Customer Service
Salman Habibullah joined Sabinsa's marketing team
in June. He is a graduate of the University of Wisconsin
(Madison) where he earned a B.S. in Consumer Sciences
(Consumer Marketing). Before joining Sabinsa, he
gained invaluable and versatile marketing experience
at Electronic Data Systems (EDS) and Mobil Corporation.
We take this opportunity to welcome Salman aboard!
Product Focus : Third U.S Patent granted
Sabinsa Corporation has been granted its third
patent by the U.S. Patent and Trademark Office on
the use of its trademarked black pepper extract
Bioperine(r). The current patent, U.S. Patent No.
5,972,382 (October 26, 1999) is a divisional application
of U.S. Patent No. 5,744,161 (1998) and U.S. Patent
No. 5,536,506 (1996). It discusses compositions
and methods for increasing nutrient bioavailability,
improving gastrointestinal (GI) absorption and systemic
utilization of nutritional materials, increasing
nutrient induced thermogenesis, and increasing lean
body mass by the administration of one or more nutritional
materials with a bioavailability enhancing amount
of piperine. The nutritional materials which may
be co-administered with Bioperine(r) include the
(e.g. curcumin, Boswellin(r), ashwagandha, ginkgo
biloba, and capsaicin),water-soluble vitamins: (e.g.
vitamin B1, vitamin B2, niacinamide, vitamin B6,
vitamin B12, folic acid, and vitamin C), fat-soluble
vitamins: (e.g. vitamin A, vitamin D, vitamin E,
and vitamin K), antioxidants: (e.g. vitamin A, vitamin
C, vitamin E, alpha-carotene, ransbeta-carotene,
beta-cryptoxanthin, lycopene, lutein/zeaxanthin,
pine bark bioflavonoids complex, germanium, selenium,
(e.g. lysine, isoleucine, leucine, threonine, valine,
tryptophan, phenylalanine, and methionine) and minerals:
(e.g calcium, iron, zinc, vanadium, selenium, chromium,
iodine, potassium, manganese, copper, and magnesium).
Bioperine® is a standardized
extract from the fruits of Piper nigrum L. (black
pepper) or Piper longum L. (long pepper). It contains
a minimum piperine content of 95% compared to the
3-9% and 3-5% found in raw forms of Piper nigrum
and Piper longum, respectively. Bioperine(r) may
be co-administered with various nutrients for both
human and animal health.
Due to its ability to increase the absorption of
nutrients comprising nutritional supplement formulations
as shown in Figures 1-4, Bioperine®
has been termed a natural Thermonutrient®
and bioavailability enhancer1,2
Figure 1. Effect
on the mean serum ß-Carotene levels during
a 14 day supplementation trial.
Figure 2. Effect of Bioperine®
on serum selenium levels during a 6 week supplementation
Efficacy of Bioperine®
on the bioavailability of vitamin B6 absorption
in human volunteers
Figure 4. Effect of Bioperine®
on serum CoQ10 levels during a 21 day supplementation
trial. Larger Image
enhances nutrient absorption by inducing thermogenesis,
the production of heat energy associated with the
digestion of food. This process, also called "food-induced
thermogenesis", is attributed to the pungent
principle piperine. The leading theory of food-induced
thermogenesis involves the autonomous nervous system,
an involuntary and independent branch of the nervous
system that controls the digestive and absorptive
processes of the GI tract via two main GI receptors,
the alpha and beta adrenergic receptors. Most of
the food or thermonutrient-induced thermogenesis
is facilitated by the beta receptors and indirectly
by cyclic adenosine 3',5' monophosphate (cAMP),
the "second messenger" to the body's hormones
Basically, the hormones of the autonomous system,
epinephrine and norepinephrine, activate the beta
receptors. Activation of the beta receptors increases
the levels of cAMP. Cyclic AMP in turn activates
a host of enzymes resulting in biochemical reactions
which produce heat energy. Piperine has been found
to stimulate the release of epinephrine which, as
described above, initiates a cascade effect resulting
in thermogenesis.3-4 Since the demand for new nutrients
to sustain thermogenesis rapidly increases, the
absorption of nutrients co-administered with as
little as 5 mg of Bioperine®
increases as well.
Proprietary information provided
by Sabinsa Corporation. All Copy Rights Reserved
Majeed, M., Badmaev, V., and Rajendran, R. (1996)
Use of piperine to increase the bioavailability
of nutritional compounds. United States Patents:
5,536,506, 5,744,161, & 5,972,382.
Kawada, T. et al. (1988) Proc. Soc. Exp. Biol.
Med. 188, 229-233.
Dora, K.A. and Clark, M.G.
(1994) Life Sci. 55(5), 389-397.
: Nature's own Thermonutrient® and Natural bioavailability
contact either Sabinsa office for a free copy of the publication
which discusses the chemistry, pharmacology, and scientific
basis of Bioperine® . Bioperine®
and Thermonutrient® are
registered trademarks of Sabinsa Corporation.
presented in the "Current Issues" Newsletter
from Sabinsa Corporation is for informational purposes
only. It is abstracted from web and print media
sources. Readers are advised to refer to the original
sources for additional information".