The Advantages of Curcuminoids + BioPerine® Combination
Absorption of a pharmacological agent through the gut is a very important issue, especially when it has poor oral bioavailability, prolonged therapeutic use, and is expensive. Such agents remain sub-therapeutic because a major portion of the dose never reaches the plasma or exerts its pharmacological effect unless and until very large doses are given, which could possibly lead to serious side effects. Any significant improvement in bioavailability results in lowering the dose and/or the frequency of administration. However, curcumin undergoes biotransformation in the GI tract. In an elegant study, Metzler.